INTERACTION OF CARBOXYMETHYL-GAMMA-CYCLODEXTRIN WITH ANTICANCER DRUGSSTUDIED BY CHARGE-TRANSFER THIN-LAYER CHROMATOGRAPHY

The interaction between 22 anticancer drugs and carboxymethyl-gamma-cy clodextrin (CM-gamma-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction wa s calculated. CM-gamma-CD formed inclusion complexes with 11 compounds , the complex always being more hydrophilic than the uncomplexed drug. The inclusion forming capacity of drugs differed considerably accordi ng to their chemical structure. Both principal component analysis and cluster analysis found a relationship between the inclusion complex fo rming capacity and hydrophobicity parameters of anticancer drugs. This result suggests that the preponderant role of hydrophobic interaction s is in inclusion complex formation.