INHIBITION OF MYELOPEROXIDASE RELEASE FROM RAT POLYMORPHONUCLEAR LEUKOCYTES BY A SERIES OF AZACHALCONE DERIVATIVES

Authors
EDWARDS ML STEMERICK DM SABOL JS DIEKEMA KA DINERSTEIN RJ
Citation
Ml. Edwards et al., INHIBITION OF MYELOPEROXIDASE RELEASE FROM RAT POLYMORPHONUCLEAR LEUKOCYTES BY A SERIES OF AZACHALCONE DERIVATIVES, Journal of medicinal chemistry, 37(25), 1994, pp. 4357-4362
Citations number
34
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
37
Issue
25
Year of publication
1994
Pages
4357 - 4362
Database
ISI
SICI code
0022-2623(1994)37:25<4357:IOMRFR>2.0.ZU;2-X
Abstract
A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of ex tracellular calcium. Structure-activity relationships are discussed.