REAGENTS FOR BIOORGANIC SYNTHESIS .6. THE DESIGN AND SYNTHESIS OF 2 NOVEL POLYFUNCTIONAL ORGANIC-REAGENTS FOR BIOMACROMOLECULAR MODIFICATION

The design, synthesis, structure, and properties of two tetrafunctiona l organic reagents, namely, xymethylamino)-(E,E)-N-(2-chloroethyl)prop enamide] (SBCCP) (1) and rboxymethylamino)-(E,E)-N-(2-oxoethyl)propena mide] (SBCOP) (2) are reported. Reagents 1 and 2 contain reactive bis( alkyl halide) and bis(aldehyde) functions, respectively, as well as bi s(carboxylic acid) moieties. The reagents have potential applications for biomacromolecular cross-linking, in particular for the cross-linki ng of hemoglobin subunits. Single-crystal X-ray diffraction data of sy nthetic intermediates (4,5, and 12) provided information about structu ral features and tether lengths of the target reagents.