CONFORMATIONAL DYNAMICS OF PROTEIN SIDE-CHAINS AND ENZYME-SUBSTRATE INTERACTION

Authors
Citation
Ae. Sitnitsky, CONFORMATIONAL DYNAMICS OF PROTEIN SIDE-CHAINS AND ENZYME-SUBSTRATE INTERACTION, Journal of biomolecular structure & dynamics, 12(2), 1994, pp. 475-486
Citations number
34
Categorie Soggetti
Biophysics,Biology
ISSN journal
07391102
Volume
12
Issue
2
Year of publication
1994
Pages
475 - 486
Database
ISI
SICI code
0739-1102(1994)12:2<475:CDOPSA>2.0.ZU;2-A
Abstract
The electric interaction of charged and polar protein side chains with dipole moments of the bonds of substrate molecules bound in enzyme ac tive sites is considered. The conformational motion of the side chains leads to the fact that the electric interaction, besides a constant ( electrostatic) part, contains a fluctuating one, which is a random for ce (noise) exerted on the substrate molecule. On the time scale of enz yme turnovers this noise can be considered as the white one with good approximation. The noise is external, and the explicit expression for its intensity has been obtained. The possible functional role of the n oise as an activating factor in enzyme catalysis is discussed.