Ae. Sitnitsky, CONFORMATIONAL DYNAMICS OF PROTEIN SIDE-CHAINS AND ENZYME-SUBSTRATE INTERACTION, Journal of biomolecular structure & dynamics, 12(2), 1994, pp. 475-486
The electric interaction of charged and polar protein side chains with
dipole moments of the bonds of substrate molecules bound in enzyme ac
tive sites is considered. The conformational motion of the side chains
leads to the fact that the electric interaction, besides a constant (
electrostatic) part, contains a fluctuating one, which is a random for
ce (noise) exerted on the substrate molecule. On the time scale of enz
yme turnovers this noise can be considered as the white one with good
approximation. The noise is external, and the explicit expression for
its intensity has been obtained. The possible functional role of the n
oise as an activating factor in enzyme catalysis is discussed.