A METHOD TO IMPROVE INTERRATER RELIABILITY OF VISUAL INSPECTION OF BRAIN MRI SCANS IN DEMENTIA

MR scanning is used in the clinical evaluation of patients with dement ia but lacks a reliable method of visual inspection. Two neurologists conducted multiple pilot trials of alternate methods for visual inspec tion of MRIs, including methods that produced at least 75% interrater agreement in repeat trials, and selected a final method for rating ven tricular:brain ratio (VBR), cortical atrophy, and white matter changes . Two other neurologists, new to the method, tested interrater reliabi lity for each component of the method after a brief training session. The correlation of VBR measurement was 0.884 (p = 0.0001). The weighte d kappa scores were 0.68 for overall frontal lobe atrophy, 0.38 for ri ght temporal lobe atrophy, 0.20 for left temporal lobe atrophy, and 0. 54 for parietal lobe atrophy. The weighted kappa scores were 0.77 for overall periventricular white matter hyperintensities and 0.72 for cen trum semiovale hyperintensities. The proposed method may provide a rap id and reliable way to assess VBR, frontal lobe atrophy, parietal lobe atrophy, and white matter changes on brain MRIs in the evaluation of dementia, but it was less reliable for the assessment of temporal lobe atrophy.