ACUTE ATAXIC NEUROPATHY WITH CROSS-REACTIVE ANTIBODIES TO GD(1B) AND GD(3) GANGLIOSIDES

Authors
WILLISON HJ ALMEMAR A VEITCH J THRUSH D
Citation
Hj. Willison et al., ACUTE ATAXIC NEUROPATHY WITH CROSS-REACTIVE ANTIBODIES TO GD(1B) AND GD(3) GANGLIOSIDES, Neurology, 44(12), 1994, pp. 2395-2397
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
44
Issue
12
Year of publication
1994
Pages
2395 - 2397
Database
ISI
SICI code
0028-3878(1994)44:12<2395:AANWCA>2.0.ZU;2-A
Abstract
We report a patient with an acute, self-limiting neuropathy consisting of ataxia and areflexia, but without ophthalmoplegia or limb weakness , with transient, high-titer serum IgG antibodies to a single NeuAc(al pha 2-8)NeuAc-linked disialosyl epitope, as found on GD(1b) and GD(3) gangliosides. The serum did not react with GQ(1b), GT(1a), or GT(1b). This atypical case, which most closely represents an incomplete Miller Fisher syndrome, indicates that anti-GD(1b)/GD(3) antibodies may be a ble to induce sensory ataxia.