SELECTIVE REGIONAL VASOCONSTRICTION UNDERLYING PRESSER EFFECTS OF GALANIN IN ANESTHETIZED POSSUMS COMPARED WITH CATS

1. Intravenous administration of porcine galanin (5 nmol kg(-1)) cause d a rise in mean blood pressure in the brush-tailed possum, Trichosuru s vulpecula, from 58 +/- 1.6 to 106 +/- 1.6 mmHg. This effect is in co ntrast to the cat, in which no significant change in blood pressure wa s recorded in response to galanin (88 +/- 2.3 vs. 86 +/- 2.4 mmHg). 2. Cardiac output and regional blood flow distribution were assessed by distribution of radioactive microspheres in four anaesthetized possums and four cats, before and after administration of galanin. 3. Cardiac output was 289.8 +/- 14.0 ml min(-1) in the cat and 189.9 +/- 25.5 mi min(-1) in the possum. Galanin administration did not significantly c hange cardiac output in either species. 4. In the possum, galanin admi nistration caused large increases in resistance to flow in the spleen, gut, adrenal glands, kidney, skin and carcass. The largest increase w as in the kidneys, where renal blood flow fell to 6% of control levels . 5. In the cat, changes in resistance were smalt. Small increases in resistance to flow in muscle and carcass were offset by small decrease s in resistance in the lungs and kidneys. 6. The results suggest that the pressor effect of galanin in the possum is the result of direct va soconstrictor action in several vascular beds, in contrast to the cat, in which such effects are few and weak.