IMPROVED SEPARATION OF DIASTEREOISOMERS IN CAPILLARY ELECTROPHORESIS USING A MIXTURE OF BETA-CYCLODEXTRIN AND TAURODEOXYCHOLATE

Authors
OKAFO GN RANA KK CAMILLERI P
Citation
Gn. Okafo et al., IMPROVED SEPARATION OF DIASTEREOISOMERS IN CAPILLARY ELECTROPHORESIS USING A MIXTURE OF BETA-CYCLODEXTRIN AND TAURODEOXYCHOLATE, Chromatographia, 39(9-10), 1994, pp. 627-630
Citations number
13
Categorie Soggetti
Chemistry Analytical
Journal title
Chromatographia → ACNP
ISSN journal
00095893
Volume
39
Issue
9-10
Year of publication
1994
Pages
627 - 630
Database
ISI
SICI code
0009-5893(1994)39:9-10<627:ISODIC>2.0.ZU;2-2
Abstract
2,3,4,6-tetra-O-acetyl-beta-D-glucopranosyl isothiocyanate derivative of a number of basic compounds, containing one chiral center, have bee n prepared. The indirect resolution of enantiomers was achieved with a high separation efficiency by capillary electrophoresis, using a sodi um taurodeoxycholate/beta-cyclodextrin system. This methodology was fo und to be superior to the resolution of the same derivatives by revers ed phase HPLC analysis. A possible mechanism for stereoselectivity is described.