THERAPEUTIC ADVANCES IN IMMUNOSUPPRESSION

Immunosuppressive therapy is appropriate for the prevention or reversa l of allograft rejection, and for the treatment of autoimmune disorder s and allergic disease. Recent advances in our understanding of the ce llular and molecular mechanisms that regulate immune responses have pa ralleled elucidation of the modes of action of a variety of therapeuti c immunosuppressive agents, both 'old' and new. These developments hav e identified potential targets for more refined and specific intervent ion strategies that are now being tested in the clinic.