The resurgence of syphilis in the United States is effecting all areas
of medical care. We describe a young female presenting with symptoms
of peptic ulcer disease who failed to respond to H2-receptor antagonis
t therapy. After further evaluation, she was diagnosed with gastric sy
philis and responded well to penicillin. Because gastric syphilis has
no pathognomonic clinical findings, the clinician needs to be aware of
this disease entity so as to make the correct diagnosis and institute
the appropriate antibiotic therapy.