ACTIVATED PARTIAL THROMBOPLASTIN TIME FOR AUTOMATED TECHNIQUES - A COMPARISON OF 2 COMMONLY USED REAGENTS

In a comparison between two widely used activated partial thromboplast in time reagents (Instrumentation Laboratories, Manchester low-opacity ), using one popular instrument (Automated Coagulation Laboratory, mod el 300R), a wide range of defects and 40 normals were tested. There wa s generally good agreement between methods, although for samples from patients on high heparin dosages the agreement was poor. The manufactu rer's recommendation for the therapeutic range for heparin for the Ins trumentation Laboratory reagent was lower than the range in current ge neral use. The Manchester reagent was more sensitive to the lupus anti coagulant.