S. Craig et al., ACTIVATED PARTIAL THROMBOPLASTIN TIME FOR AUTOMATED TECHNIQUES - A COMPARISON OF 2 COMMONLY USED REAGENTS, British journal of biomedical science, 51(4), 1994, pp. 321-327
In a comparison between two widely used activated partial thromboplast
in time reagents (Instrumentation Laboratories, Manchester low-opacity
), using one popular instrument (Automated Coagulation Laboratory, mod
el 300R), a wide range of defects and 40 normals were tested. There wa
s generally good agreement between methods, although for samples from
patients on high heparin dosages the agreement was poor. The manufactu
rer's recommendation for the therapeutic range for heparin for the Ins
trumentation Laboratory reagent was lower than the range in current ge
neral use. The Manchester reagent was more sensitive to the lupus anti
coagulant.