EFFICACY AND TOLERABILITY OF CILAZAPRIL IN PATIENTS WITH ESSENTIAL-HYPERTENSION

This study investigated the effect of the angiotensin-converting enzym e (ACE) inhibitor cilazapril on blood pressure in patients with essent ial hypertension [defined as a sitting diastolic blood pressure (DBP) between 95-120 mm Hg]. The study group comprised 43 patients (24 men a nd 19 women; mean age, 51 +/- 10 years) with uncomplicated essential h ypertension. In an open single-center design, all subjects were treate d with a once-daily dose of cilazapril for 6 weeks, following a 1-week washout period. The initial dose was 2.5 mg/day. In nonresponders, th is dose was doubled after 3 weeks of treatment. Thirty-eight patients completed the study. One was withdrawn due to symptomatic hypotension, and four others due to noncompliance. Treatment produced a useful and significant reduction in blood pressure (systolic from 155 +/- 3 to 1 38 +/- 3 mm Hg, p < 0.01; diastolic from 103 +/- 1 to 90 +/- 2 mm Hg, p < 0.001). No significant variations in mean heart rate were recorded . Normalization of DBP, or its reduction by >10 mm Hg, was found in 28 patients (efficacy in 74% of cases). Cough was reported by one patien t. There was no significant variation in laboratory profiles during th e trial. Cilazapril proved to be a well-tolerated antihypertensive dru g effective on a once-daily regimen in a high percentage of patients w ith essential hypertension.