GAMMA-PROBE-GUIDED SENTINEL NODE BIOPSY TO SELECT PATIENTS WITH MELANOMA FOR LYMPHADENECTOMY

A novel approach is described by which to identify the sentinel lymph node in patients with stage I melanoma. The technique involves a combi nation of intradermal patent blue V injection and gamma probe-assisted surgery. Eleven patients with previously resected cutaneous melanoma, clinical stage I (Breslow thickness 1.35-3.20 mm), underwent sentinel node biopsy. Before surgery lymphoscintigraphy was performed to evalu ate the pathways of lymphatic drainage from the site of the previously resected melanoma. A handheld gamma probe was used to localize the se ntinel node and to define the exact site of incision. At the same time , patent blue V (0.1-0.2 ml)was injected intracutaneously on either si de of the scar to visualize the afferent lymphatic ducts and lymph nod es. By combining the use of the gamma probe and vital dye shining, the sentinel node could easily be localized and identified in all 11 pati ents. After removal of the sentinel node(s) no residual radioactivity could be traced. In four patients with micrometastases in the sentinel node standard lymph node dissection was performed, including excision of the biopsy site; in only one lymphadenectomy specimen were microme tastases found in two other lymph nodes.