INFLUENCE OF 22-WEEK NICOTINE TREATMENT AND DIETARY COPPER AN BLOOD-PRESSURE AND INDEXES OF THE ANTIOXIDANT SYSTEM IN MALE SPONTANEOUS HYPERTENSIVE RATS
Lm. Bui et al., INFLUENCE OF 22-WEEK NICOTINE TREATMENT AND DIETARY COPPER AN BLOOD-PRESSURE AND INDEXES OF THE ANTIOXIDANT SYSTEM IN MALE SPONTANEOUS HYPERTENSIVE RATS, Biological trace element research, 46(1-2), 1994, pp. 67-78
Nicotine treatment and copper (Cu) deficiency have been associated wit
h an increased production of reactive oxygen species that may contribu
te to the development and/or progression of cardiovascular diseases (C
VD). The present study investigated the influence of dietary Cu intake
on the response to chronic nicotine treatment in spontaneous hyperten
sive rats (SHR) with respect to tissue trace mineral levels, several c
omponents of the oxidant defense system, and Lipid peroxidation rates.
SHR weighing 100-110 g were fed a Cu deficient diet (-Cu) (0.5 mu g C
u/g) for 14 d prior to nicotine treatment.