INFLUENCE OF 22-WEEK NICOTINE TREATMENT AND DIETARY COPPER AN BLOOD-PRESSURE AND INDEXES OF THE ANTIOXIDANT SYSTEM IN MALE SPONTANEOUS HYPERTENSIVE RATS

Authors
BUI LM KEEN CL DUBICK MA
Citation
Lm. Bui et al., INFLUENCE OF 22-WEEK NICOTINE TREATMENT AND DIETARY COPPER AN BLOOD-PRESSURE AND INDEXES OF THE ANTIOXIDANT SYSTEM IN MALE SPONTANEOUS HYPERTENSIVE RATS, Biological trace element research, 46(1-2), 1994, pp. 67-78
Citations number
39
Categorie Soggetti
Biology
Journal title
Biological trace element research → ACNP
ISSN journal
01634984
Volume
46
Issue
1-2
Year of publication
1994
Pages
67 - 78
Database
ISI
SICI code
0163-4984(1994)46:1-2<67:IO2NTA>2.0.ZU;2-5
Abstract
Nicotine treatment and copper (Cu) deficiency have been associated wit h an increased production of reactive oxygen species that may contribu te to the development and/or progression of cardiovascular diseases (C VD). The present study investigated the influence of dietary Cu intake on the response to chronic nicotine treatment in spontaneous hyperten sive rats (SHR) with respect to tissue trace mineral levels, several c omponents of the oxidant defense system, and Lipid peroxidation rates. SHR weighing 100-110 g were fed a Cu deficient diet (-Cu) (0.5 mu g C u/g) for 14 d prior to nicotine treatment.