THE ROLE OF ATP AS A MEDIATOR IN THE ACTION OF IRON COMPLEXES ON CELLULAR CALCIUM HOMEOSTASIS

The effects of the interaction between low molecular weight iron compl exes (citrate, lactate, and ATP complexes) with Am and proteins, on th e modification of Ehrlich carcinoma cell calcium homeostasis have been studied. In that modification the ferric-ATP complex shows much highe r activity than the others. Sodium ATP, by iron translocation from cit rate and lactate, increases their activity. This phenomenon implicates ATP as a-mediator on the cellular activity of the complexes. Proteins , particularly ferritin, appear to moderately reduce their activity, w hereas glutathione and ascorbic acid, acting as Lipid, peroxidation-in hibitors, show only a slight reduction of the iron complex's effects o n cellular calcium uptake.