NEBULIZED FUROSEMIDE IN INFANTS WITH BRONCHOPULMONARY DYSPLASIA

The effects of 0.1 mg, 0.25 mg, 0.50 mg, and 1.0 mg of nebulized furos emide per kilogram of body weight on pulmonary functions were studied in eight preterm infants with bronchopulmonary dysplasia who were supp orted by mechanical ventilation, Doses of 1 mg/kg significantly improv ed lung compliance (51% at 2 hours after nebulization), pulmonary resi stance (28% at 1 hour), and tidal volume (43% at 1 hour), starting as early as 30 minutes after the dose; the effect lasted for at least 4 h ours in many of the infants and was not associated with diuresis or re nal side effects.