EFFECTS OF THE LONG-ACTING SOMATOSTATIN ANALOG OCTREOTIDE ON ABOMASALFUNCTION AND PLASMA-LEVEL OF INSULIN AND GLUCAGON IN SHEEP

Authors
Citation
K. Holtenius, EFFECTS OF THE LONG-ACTING SOMATOSTATIN ANALOG OCTREOTIDE ON ABOMASALFUNCTION AND PLASMA-LEVEL OF INSULIN AND GLUCAGON IN SHEEP, Acta veterinaria Scandinavica, 35(3), 1994, pp. 235-241
Citations number
28
Categorie Soggetti
Veterinary Sciences
ISSN journal
0044605X
Volume
35
Issue
3
Year of publication
1994
Pages
235 - 241
Database
ISI
SICI code
0044-605X(1994)35:3<235:EOTLSA>2.0.ZU;2-Z
Abstract
The effects of the long-acting somatostatin analogue octreotide were s tudied in sheep. Octreotide was given subcutaneously at a dose of 0.75 mu g/kg body weight and, as a control, 0.9% saline solution was injec ted in a change-over design. Octreotide inhibited abomasal acid secret ion and retarded the turnover time of digesta through the abomasum. Th e plasma levels of insulin and glucagon decreased due to the octreotid e injection, while the plasma glucose level was not affected. The effe cts of octreotide lasted for 3-4h. There were no significant effects o f the saline injection. The effects of octreotide showed similarities with results from previous studies on monogastric species.