GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC CONFIRMATION OF 10 N-METHYLCARBAMATE INSECTICIDES IN LIVER

A gas chromatographic/mass spectrometric (GC/MS) confirmation procedur e for 10 phenyl-N-methyl-carbamate insecticides in liver tissue was de veloped. The extract from liquid chromatography (LC) is purified with a C-18 solid-phase extraction cartridge and then derivatized with hept afluorobutyric anhydride; the derivative is injected for analysis by G C/MS with electron ionization and multiple ion monitoring. The identit y of the derivative is confirmed by comparison of its retention time a nd relative intensity data with those of a standard. Liver extracts fr om the LC procedure containing carbamates at 10 ppb levels were succes sfully confirmed by this procedure.