Laboratory testing of dentin adhesive systems still requires corrobora
tion by long-term clinical trials for their ultimate clinical effectiv
eness to be validated. The objective of this clinical investigation wa
s to evaluate, retrospectively, the clinical effectiveness of earlier-
investigated dentin adhesive systems (Scotchbond, Gluma, Clearfil New
Bond, Scotchbond 2, Tenure, and Tripton), and to compare their clinica
l results with those obtained with four modern total-etch adhesive sys
tems (Bayer exp. 1 and 2, Clearfil Liner Bond System, and Scotchbond M
ulti-Purpose). In total, 1177 Class V cervical lesions in the teeth of
346 patients were restored following two cavity designs: In Group A,
enamel was neither beveled nor intentionally etched, as per ADA guidel
ines; in Group B, adjacent enamel was beveled and conditioned. Clinica
l retention rates definitely indicated the improved clinical efficacy
of the newest dentin adhesives over the earlier systems. With regard t
o adhesion strategy, adhesive systems that removed the smear layer and
concurrently demineralized the dentin surface layer performed clinica
lly better than systems that modified the disorderly layer of smear de
bris without complete removal. Hybridization by resin interdiffusion i
nto the exposed dentinal collagen layer, combined with attachment of r
esin tags into the opened dentin tubules, appeared to be essential for
reliable dentin bonding but might be insufficient by itself. The addi
tional formation of an elastic bonding area as a polymerization shrink
age absorber and the use of a microfine restorative composite apparent
ly guaranteed an efficient clinical result. The perfect one-year reten
tion recorded for Clearfil Liner Bond System and Scotchbond Multi-Purp
ose must be confirmed at later recalls.