RELATIONSHIP BETWEEN ALPHA(1)-ANTITRYPSIN INACTIVATION AND TUMOR-NECROSIS-FACTOR-ALPHA CONCENTRATION IN THE SYNOVIAL-FLUID OF PATIENTS WITHRHEUMATOID-ARTHRITIS

Authors
CHIDWICK K WHICHELOW CE ZHANG Z FAIRBURN K SACHS JA BLAKE DR WINYARD PG
Citation
K. Chidwick et al., RELATIONSHIP BETWEEN ALPHA(1)-ANTITRYPSIN INACTIVATION AND TUMOR-NECROSIS-FACTOR-ALPHA CONCENTRATION IN THE SYNOVIAL-FLUID OF PATIENTS WITHRHEUMATOID-ARTHRITIS, Arthritis and rheumatism, 37(12), 1994, pp. 1723-1726
Citations number
20
Categorie Soggetti
Rheumatology
Journal title
Arthritis and rheumatism → ACNP
ISSN journal
00043591
Volume
37
Issue
12
Year of publication
1994
Pages
1723 - 1726
Database
ISI
SICI code
0004-3591(1994)37:12<1723:RBAIAT>2.0.ZU;2-U
Abstract
To examine the relationship between alpha(1)-antitrypsin (alpha(1)AT) specific activity and tumor necrosis factor alpha(TNF alpha) concentra tion in synovial fluid from 48 patients with rheumatoid arthritis. Met hods.The specific activity of alpha(1)AT was calculated from the measu rement of alpha(1)AT concentration (by rocket immunoelectrophoresis) a nd elastase inhibitory capacity. TNF alpha was detected by enzyme-link ed immunosorbent assay. Results. TNF alpha concentrations correlated w ith the extent of alpha(1)AT inactivation. Conclusion. Our findings ar e consistent with a role of elastase in TNF alpha release within the i nflamed joint.