ALTERED GABAERGIC AND GLUTAMATERGIC TRANSMISSION IN AUDIOGENIC SEIZURE-SUSCEPTIBLE MICE

The C57BL/10 SPS/sps mouse mutant are audiogenic seizure-susceptible. The enzymatic activities of glutamate decarboxylase (GAD), GABA aminot ransferase (GABA-T), alanine aminotransferase (ALA-T), aspartate amino transferase (ASP-T), and glutamate dehydrogenase (GDH) of whole brain supernatant are significantly reduced in these epileptic mice. GABA up take is decreased in cortex, midbrain, and pens medulla. Previous stud ies showed the presence of two sodium-dependent GLU uptake systems in normal (SPS/SPS) mice. Glutamate U-max by System 1 is significantly de creased in these mice, whereas the U-max value for System 2 is signifi cantly increased in the epileptic mice.