P. Jha et al., EFFECTS OF NORETHISTERONE ACETATE RELEASED FROM A SILASTIC IMPLANT ONSERUM COPPER AND ZINC LEVELS IN WOMEN, Drug investigation, 8(6), 1994, pp. 383-386
The serum levels of copper and zinc were estimated by atomic absorptio
n spectrometry in 7 women with silastic implants releasing norethister
one acetate 140 mu g/day. No appreciable change was observed in the ci
rculating concentrations of either of the trace metals after use of th
e implant for a period of up to 12 months. There was also no change in
the serum copper and zinc concentrations during the proliferative and
secretory phases of the normal menstrual cycles in 15 women.