Sterol carrier protein X (SCPx) is a 58-kDa protein that is localized
to peroxisomes, The amino acid sequence of the protein suggests that S
CPx may function as a thiolase, The gene encoding SCPx also codes for
a 15.3-kDa protein called sterol carrier protein 2 (SCP2). Here we rep
ort the structure of this gene (SCPS), which spans approximately 80 kb
and consists of 16 exons and 15 introns, Multiple transcription start
sites were identified. The 5' flanking region has characteristics of
other peroxisomal protein promoters, which include the absence of a TA
TA box and a G+C-enriched region containing several reverse GC boxes.
(C) 1994 Academic Press, Inc.