GENETIC-MAPPING OF 2 MOUSE HOMEOBOX GENES TLX-1 AND TLX-2 TO MURINE CHROMOSOME-19 AND CHROMOSOME-6

We have previously cloned two mouse homeobox genes Tlx-1 (T-cell leuke mia homeobox gene-1) and a related gene Tlx-2 based on their homology to human HOX11, a putative proto oncogene involved in human T-cell leu kemia. We have mapped Tlx-1 to mouse chromosome 19 and Tlx-2 to chromo some 6 by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus) F1 x M. spretus. The proposed gene orders and genetic d istances for Tlx-1 and Tlx-2 are centromere 19-Lpc-1-(25.53 cM)-Pltr-4 -(5.32 cM)-Tlx-1-(3.19 cM)-Ins-1-(7.45 cM)-Xmv-18, and centromere 6-Tc rb-(12.90 cM)-Mltr-3-(10.75 cM)-Tlx-2-(18.42 cM)-Xmv-6. (C) 1994 Acade mic Press, Inc.