CADMIUM-INDUCED LIPID-PEROXIDATION IN RAT-LIVER SLICES - A POSSIBLE INVOLVEMENT OF HYDROXYL RADICALS

Authors
SARKAR S BHATNAGAR D YADAV P
Citation
S. Sarkar et al., CADMIUM-INDUCED LIPID-PEROXIDATION IN RAT-LIVER SLICES - A POSSIBLE INVOLVEMENT OF HYDROXYL RADICALS, Toxicology in vitro, 8(6), 1994, pp. 1239-1242
Citations number
20
Categorie Soggetti
Toxicology
Journal title
Toxicology in vitro → ACNP
ISSN journal
08872333
Volume
8
Issue
6
Year of publication
1994
Pages
1239 - 1242
Database
ISI
SICI code
0887-2333(1994)8:6<1239:CLIRS->2.0.ZU;2-7
Abstract
Cadmium-induced lipid peroxidation (LPO) in the presence of various hy droxyl radical-generating media was studied in rat liver slices, In th e absence of such media, Cd showed an inhibitory action on LPO in vitr o. Cd-induced LPO in liver slices in the presence of OH radical-genera ting media was inhibited by antioxidants. The findings indicate that C d induced LPO as a result of the presence of transition metal ions and the generation of hydroxyl radicals.