THE EFFECT OF CISAPRIDE AND METOCLOPRAMIDE ON HUMAN DIGESTIVE AND INTERDIGESTIVE ANTRODUODENAL MOTILITY

Background: To date, there is little information available about the e ffect of cisapride and metoclopramide on gastroduodenal pressure waves and their space/time orientation. Methods: Antroduodenal pressures (t wo antral, three duodenal recording sites) were measured in nine healt hy volunteers. Cisapride (10 mg), metoclopramide (10 mg), and placebo were administered intravenously on different days in a randomized mann er. Results: During the interdigestive state cisapride increased the m otility index significantly in the antrum (p < 0.05) and duodenum (p < 0.005), metoclopramide only in the duodenum (p < 0.01). Antroduodenal coordination was significantly (p < 0.01) improved by cisapride but n ot by metoclopramide. There is evidence of antroduodenal coordination even during the interdigestive state. After a liquid test meal an incr ease in the antroduodenal motility index (p < 0.05), in the rate of pr ograde antroduodenal peristalsis (p < 0.01), and in antroduodenal coor dination (p < 0.01) was caused by cisapride but not metoclopramide. Bo th prokinetics decreased (p < 0.01) retrograde antroduodenal peristals is. Conclusion: Cisapride significantly improves antroduodenal coordin ation and antroduodenal motility; metoclopramide seems to be less effe ctive.