CHROMOSOME-8 ALTERATIONS ACCOMPANY TUMORIGENESIS IN RENIN-SV40 T-ANTIGEN TRANSGENIC MICE

s.c. and abdominal tumors from interspecific hybrid, transgenic mice c ontaining the SV40 early region linked to a renin enhancer/promoter we re analyzed for loss of heterozygosity to identify chromosomal regions involved in tumorigenesis, A very high frequency of loss of heterozyg osity/ partial loss of heterozygosity or allelic imbalance involving t he distal regions of chromosome 8 was observed in the s.c. tumors (76% ) with frequent amplification (3-6 times) of the corresponding proxima l regions including Junb, suggesting that chromosome 8 breakage and am plification promotes tumorigenesis in these mice.