CLONING AND CHARACTERIZATION OF 2 NOVEL HUMAN CDNAS (NELL1 AND NELL2)ENCODING PROTEINS WITH 6 EGF-LIKE REPEATS

Authors
WATANABE TK KATAGIRI T SUZUKI M SHIMIZU F FUJIWARA T KANEMOTO N NAKAMURA Y HIRAI Y MAEKAWA H TAKAHASHI E
Citation
Tk. Watanabe et al., CLONING AND CHARACTERIZATION OF 2 NOVEL HUMAN CDNAS (NELL1 AND NELL2)ENCODING PROTEINS WITH 6 EGF-LIKE REPEATS, Genomics, 38(3), 1996, pp. 273-276
Citations number
7
Categorie Soggetti
Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
38
Issue
3
Year of publication
1996
Pages
273 - 276
Database
ISI
SICI code
0888-7543(1996)38:3<273:CACO2N>2.0.ZU;2-3
Abstract
From a human fetal-brain cDNA library we isolated two novel genes enco ding peptides containing six EGF-like repeats. Both showed significant homologies with nel, a gene strongly expressed in neural tissues of c hicken. The cDNAs, designated NELL1 (nel-like, type 1) and NELL2 (nel- like, type 2), contained open reading frames encoding 810 and 816 amin o acids, respectively. NELL2 is strongly expressed in brain of adult a nd fetus but only weakly in fetal kidney. NELL1 and NELL2 were mapped by FISH to chromosomal bands 11p15.1-p15.2 and 12q13.11-q13.2, respect ively. (C) 1996 Academic Press, Inc.