Ga. Kumari et al., BIOSYNTHESIS OF ISOPRENOID COMPOUNDS IN CATTLE FILARIAL PARASITE SETARIA-DIGITATA, Biochemical and biophysical research communications, 205(1), 1994, pp. 24-29
The biological significance of isoprenoid compounds such as ubiquinone
s, prenols and sterols have been well established. The presence and bi
ological function of the two quinones Q(6) and Q(8) in the cattle fila
rial parasite Setaria digitata have already been reported. Inhibition
of the function of quinone was already shown to be an effective means
of controlling the filarial parasite. Detailed investigations of the n
on-saponifiable lipids from S. digitata using column, thin layer, reve
rse phase and high performance liquid chromatography showed the presen
ce and formation of isoprenoid compounds such as prenols and sterols,
in addition to the two quinones. Blocking the biosynthesis of these us
eful compounds may prove to be an additional means of control of filar
ial parasites. (C) 1994 Academic press, Inc.