SEVERAL LIVER-SPECIFIC DNASE HYPERSENSITIVE SITES ARE PRESENT IN THE INTERGENIC REGION SEPARATING HUMAN PLASMINOGEN AND APOPROTEIN(A) GENES

The genes coding for plasminogen and apoprotein(a) are clustered, toge ther with two related genes, on the telomeric region of chromosome 6 a t band 6q26-27. Moreover, the two genes are 40 Kb apart and transcript ionally pointing to opposite directions. Plasminogen and apoprotein(a) share a high degree of homology in the promoter and 5' flanking regio ns and their expression is mainly confined to liver. To assess whether common controlling elements mediate the tissue specific expression of these two genes, the region between them was investigated for DNase h ypersensitive sites in hepatic cell nuclei. (C) 1994 Academic Press, I nc.