STABILITY OF AN ORAL MIDAZOLAM SOLUTION FOR PREMEDICATION IN PEDIATRIC-PATIENTS

The objectives of this study were to assess the stability of a 1 mg/ml oral midazolam solution elaborated by our Hospital Pharmacy Service, and to confirm its clinical effect in pre-surgical paediatric patients . The solution's stability was tested by determining its pH and its UV -visible absorption spectrum at room temperature for up to 60 days. A high performance liquid chromatography method was used to confirm it. There was no significant change in pH value of either the test or a co ntrol solution. No loss of midazolam could be detected during the test . The Anaesthesiology Service assessed the sedation quality (very good , good, bad) and the venous puncture response, 20 minutes after the ad ministration of 0.3 mg/kg of an oral midazolam solution. Twenty childr en were examined (age: 4-7 years). In addition, the haemodynamic and v entilatory functions were I evaluated.