INHIBITORS OF ATP-SENSITIVE POTASSIUM CHANNELS STIMULATE INTESTINAL CHOLECYSTOKININ SECRETION

Recently, a role for adenosine 5'-triphosphate(ATP)-sensitive potassiu m channels in the regulation of cholecystokinin (CCK) secretion has be en described in STC-1 cells, an intestinal CCK-secreting cell line. To examine whether a similiar mechanism might participate in the regulat ion of hormone secretion from native CCK cells, the effects of two est ablished inhibitors of ATP-sensitive potassium channels (e.g. glucose, disopyramide) were examined on CCK release from dispersed murine inte stinal cells. Both glucose and disopyramide were found to stimulate CC K secretion. Furthermore, CCK release induced by glucose was inhibited by the calcium channel blocker diltiazem. It is concluded that, ATP-s ensitive potassium channels may play a role in the regulation of intes tinal CCK secretion.