ANOTHER ARAB PATIENT WITH OVERLAP OF VARADI-PAPP OPITZ TRIGONOCEPHALYSYNDROMES/

We describe a Bedouin boy with multiple congenital anomalies/mental re tardation (MCA/MR), He has frontal bossing, ridged metopic suture, bil ateral ptosis, right squint, depressed nasal bridge, small nose, antev erted nostrils, lobulated tongue, polydactyly of both hands, microphal lus, hypoplastic scrotum, microtestes, dysgenesis of corpus callosum, and a Dandy-Walker variant, This phenotype overlaps both the Varadi-Pa pp syndrome (OFD VI) and Opitz trigonocephaly (C syndrome). This pheno typic overlap is discussed in light of the concept of splitting and lu mping in genetic diseases. (C) 1997 Wiley-Liss, Inc.