TRISOMY-1 IN A CLINICALLY RECOGNIZED PREGNANCY

Cytogenetic analysis of products of conception has identified trisomie s for all human chromosomes except for chromosome 1. Presented here is a patient with clinical signs of pregnancy, including increasing hCG levels and evidence of a gestational sac on ultrasound. However, the p regnancy was lost between 8-9 weeks post-LMP with the diagnosis of a b lighted ovum. Cytogenetic analysis of cultured chorionic villi demonst rated a 47,XY,+1 chromosome complement in all cells. This is the first reported case of nonmosaic trisomy 1 in a clinically recognized human pregnancy.