ACTIVITY OF PP(60C-SRC) IN 60 DIFFERENT CELL-LINES DERIVED FROM HUMANTUMORS

The activity of the protein tyrosine kinase pp60(c-src) was determined for each of the 60 human cell lines in the panel used by the National Cancer Institute for the random screening of potential anticancer dru gs. The leukemia, lymphoma, melanoma, and small-cell lung cancer deriv ed cell lines had low pp60(c-src) activity. Surprisingly, non-small-ce ll lung and ovarian cell lines had a median pp60(c-src) activity which was greater than that of the panel of cells representing colon cancer , which is most often associated with elevated pp60(c-src) activity. T his data defines homologous cell lines which contain low and high pp60 (c-src) activity which will aid attempts to understand the role of thi s enzyme in human cancer.