INHIBITORY EFFECTS OF COMBINED ADMINISTRATION OF UFT AND KRESTIN ON INTRAPERITONEAL METASTASES IN MICE

Authors
TAKENOSHITA S HASHIZUME T ASAO T NAKAMURA JI YAJIMA Y SHINOZAKI K SHITARA Y TSUKADA K KOITABASHI H KATOH R NAGAMACHI Y
Citation
S. Takenoshita et al., INHIBITORY EFFECTS OF COMBINED ADMINISTRATION OF UFT AND KRESTIN ON INTRAPERITONEAL METASTASES IN MICE, Oncology Reports, 1(4), 1994, pp. 727-730
Citations number
28
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
1
Issue
4
Year of publication
1994
Pages
727 - 730
Database
ISI
SICI code
1021-335X(1994)1:4<727:IEOCAO>2.0.ZU;2-4
Abstract
In this study we investigated the effect of combined administration of UFT and Krestin (PSK) on the growth of intraperitoneal metastasis and temporal changes in the immune-endocrine system under this immunochem otherapy. At 7 days, Plasma ACTH levels of the PSK group were signific antly lower than that of the control group (p<0.01). At 14 days, the t umor weight in the combined and the PSK alone group was significantly decreased, compared to the control group (p<0.05). Serum IAP levels of the UFT group were significantly lower than that of the control group (p<0.05). Serum cortisol levels of the combined group were lower than that of the other groups.