RELATIONSHIP BETWEEN NM23 EXPRESSION AND AXILLARY AND INTERNAL MAMMARY LYMPH-NODE METASTASES IN INVASIVE BREAST-CANCER

We examined the relationship between nm23 expression and clinicopathol ogical variables in 144 patients with invasive breast cancer to assess the role of nm23 expression in estimating prognosis. Expression of nm 23 was significantly associated with axillary lymph node (AX) metastas es (p=0.0359) and internal mammary lymph node (IMN) metastases (p=0.01 46), but not with age, menopausal status, histological type or grade, or tumor size. A univariate study revealed that survival significantly correlated with tumor size, AX and IMN metastases, whereas nm23 expre ssion did not appear to be a significant prognostic factor. Among pati ents with negative AX, however, survival in patients without nm23 expr ession was lower than in those with nm23 expression (p=0.0778). Surviv al in patients with IMN metastases was significantly lower than those without IMN metastases among patients with positive AX (p=0.0073). In a multivariate study, AX and IMN metastases, and nm23 expression appea red to be significant prognostic factors for survival. This study sugg ests that nm23 expression may be an additional prognostic factor in pa tients with negative AX, while IMN metastases are an additional progno stic factor in those with positive AX.