FLUORO-BORON COMPLEXES AS BIOCIDES - SYNTHETIC, STRUCTURAL AND BIOLOGICAL ASPECTS

The present account deals with the synthesis, stereochemistry and biol ogical properties of coordinatively saturated difluoroboron(III) compo unds. The ligands used during the present investigations were prepared by the condensation of [1-(thien-2-yl)-ethanone], [1-(pyridin-2-yl)et hanone], [1-(furan-2-yl)ethanone], [1-(naphthen-2-yl)ethanone] and [(t hien-2-yl)methanal] with 2-mercapto-aniline. The unimolar reactions be tween borontrifluoride-acetic acid and these ligands have produced BF2 (NS) type of biologically active complexes. The quantitative and spect ral analyses comprising u.v., i.r. and n.m.r. (H-1, B-11, C-13 and F-1 9) helped in establishing the structures of the resulting complexes. I n the quest for better fungicides and bactericides, studies were condu cted to assess the growth inhibiting potential of the synthesized comp lexes against various fungal and bacterial strains. The studies demons trate that the concentration reached levels which are sufficient to in hibit and kill the pathogens.