The underdetermination of theory by evidence must be distinguished fro
m holism. The latter is a doctrine about the testing of scientific hyp
otheses; the former is a thesis about empirically adequate logically i
ncompatible global theories or ''systems of the world''. The distincti
on is crucial for an adequate assessment of the underdetermination the
sis. The paper shows how some treatments of underdetermination are vit
iated by failure to observe this distinction, and identifies some nece
ssary conditions for the existence of multiple empirically equivalent
global theories. We consider how empiricists should respond to the pos
sibility of such systems of the world.