IMMUNOCYTOCHEMICAL LOCALIZATION OF AMPA SELECTIVE GLUTAMATE-RECEPTOR SUBUNITS IN THE RAT COCHLEA

Authors
KURIYAMA H JENKINS O ALTSCHULER RA
Citation
H. Kuriyama et al., IMMUNOCYTOCHEMICAL LOCALIZATION OF AMPA SELECTIVE GLUTAMATE-RECEPTOR SUBUNITS IN THE RAT COCHLEA, Hearing research, 80(2), 1994, pp. 233-240
Citations number
46
Categorie Soggetti
Neurosciences,Acoustics
Journal title
Hearing research → ACNP
ISSN journal
03785955
Volume
80
Issue
2
Year of publication
1994
Pages
233 - 240
Database
ISI
SICI code
0378-5955(1994)80:2<233:ILOASG>2.0.ZU;2-E
Abstract
The localization of subunits of the alpha-amino-3-hydroxy-5-methyl-4-i soxazole propionic acid (AMPA) selective glutamate receptor, termed Gl utamate receptor (GluR) was examined in the rat cochlea using affinity purified polyclonal antibody to GluR subunits (GluR 1-4). GluR 2/3 an d GluR 4 immunoreactive (IR) staining was observed in rat spiral gangl ion cells, while GluR 1 IR was not. GluR 4 IR staining was also seen i n puncta at inner and outer hair cell bases. These results suggest tha t GluR 2/3 and GluR 4 are components of excitatory amino acid synapses in the rat cochlea.