Dm. Silverstein et al., SEQUENTIAL OCCURRENCE OF IGA NEPHROPATHY AND HENOCH-SCHONLEIN PURPURA- SUPPORT FOR COMMON PATHOGENESIS, Pediatric nephrology, 8(6), 1994, pp. 752-753
We report a patient who developed Henoch-Schonlein purpura (HSP) 13 ye
ars after he presented with IgA nephropathy (IgAN). In both HSP and Ig
AN renal biopsy most commonly reveals focal proliferative glomerulonep
hritis on light microscopy and immunofluorescence displays mesangial I
gA deposits. In addition, patients with HSP or IgAN have elevated seru
m IgA levels, circulating IEA immune complexes, IgA-bearing lymphocyte
s, immunoglobulin-producing cells, and binding of IgG to glomerular co
mponents of similar molecular weight. The occurrence of both diseases
in the same patient or the same families and the presence of immune ab
normalities compatible with HSP or IgAN in relatives of patients with
these diseases suggest a common pathogenesis,