P53 BUT NOT ERBB-2 EXPRESSION IS ASSOCIATED WITH RAPID TUMOR PROLIFERATION IN URINARY-BLADDER CANCER

Citation
H. Moch et al., P53 BUT NOT ERBB-2 EXPRESSION IS ASSOCIATED WITH RAPID TUMOR PROLIFERATION IN URINARY-BLADDER CANCER, Human pathology, 25(12), 1994, pp. 1346-1351
Citations number
58
Categorie Soggetti
Pathology
Journal title
ISSN journal
00468177
Volume
25
Issue
12
Year of publication
1994
Pages
1346 - 1351
Database
ISI
SICI code
0046-8177(1994)25:12<1346:PBNEEI>2.0.ZU;2-2
Abstract
Tumor proliferation in bladder cancer is associated with tumor behavio r. To assess the association between Ki-67 labeling index (LI), p53, a nd c-erbB-2 overexpression, formalin-fixed tissue samples of 160 patie nts with transitional cell carcinoma (TCC) of the urinary bladder were studied by immunohistochemistry. Ki-67 LI was strongly associated wit h tumor stage (P < .0001), tumor grade (P < .0001), and p53 status (P = .0014) but not with erbB-2 overexpression (P > .2). Ki-67 LT was hig her in p53-positive tumors (19%) than in p53-negative tumors (14%) whe n all stages were compared. Ki-67 LI was independent of p53 expression in pTa tumors (p53-positive, 9%; p53-negative, 11%), showing that p53 overexpression alone is not sufficient to induce rapid tumor cell pro liferation in pTa tumors. Ki-67 LI also was independent of p53 express ion in pT2 to pT4 tumors (p53-positive, 20%; p53-negative, 23%), indic ating that p53 expression is not necessary for rapid tumor cell prolif eration in advanced stages. However, there was a striking difference i n Ki-67 LI between p53-positive pT1 tumors (22.0% +/- 8.8 standard dev iation [SD]; n = 20) and p53-negative pT1 tumors (9.7 +/- 8.3 SD; n = 22; P=.0001). These results suggest that increased proliferation in p5 3-positive pT1 tumors is caused by additional alterations that occur d uring tumor progression. Copyright (C) 1994 by W.B. Saunders Company