SYNTHESIS OF 2'-HEPTYLCARBAMOYLOXY-2-METHYL-6,7-BENZOMORPHAN - A NEW ANALOG OF HEPTYLPHYSOSTIGMINE (MF-201)

Authors
BRUFANI M FILOCAMO L IMBRIANI E LAPPA S MANNINA L
Citation
M. Brufani et al., SYNTHESIS OF 2'-HEPTYLCARBAMOYLOXY-2-METHYL-6,7-BENZOMORPHAN - A NEW ANALOG OF HEPTYLPHYSOSTIGMINE (MF-201), Il Farmaco, 49(11), 1994, pp. 743-745
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
11
Year of publication
1994
Pages
743 - 745
Database
ISI
SICI code
0014-827X(1994)49:11<743:SO2-AN>2.0.ZU;2-U
Abstract
The synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan is de scribed. The compound in structurally related to the cholinesterase in hibitor heptylphysostigmine (MF 201) because the angular methyl group of the esoroline nucleus has been changed into a bridging carbon and t he anilinic nitrogen has been raplaced by a methylene group. This comp ound proved to be a potent cholinesterase in vitro inhibitor.