DISSEMINATED INTRAVASCULAR COAGULATION IN A MAN WITH METACHRONOUS BONE METASTASIS FROM GASTRIC-CANCER - CASE-REPORT

We report on a case of multiple bone metastasis and disseminated intra vascular coagulation (DIG) in a 49-year-old Japanese man. He underwent total gastrectomy for advanced gastric cancer in July 1992, He was di agnosed as a case of multiple bone metastasis in August 1993. Severe a nemia, thrombocytopenia, and elevated fibrinogen degradative products were indicative of DIG. He was treated with sequential i.v. administra tion of methotrexate (MTX) and 5-fluorouracil (5-FU) and continuous i. v. infusion of heparin and gabexate mesilate. After two weeks of treat ment with MTX combined with 5-FU, the findings of DIC disappeared and his general condition improved dramatically.