REARRANGED P53 GENE WITH LOSS OF NORMAL ALLELE IN A LOW-GRADE NONRECURRENT GLIOMA

We are studying the p53 gene profile in primary glial tumors by seekin g alterations in the hybridization pattern of the tumor DNA probed wit h a p53 gene probe. This report documents a rearranged p53 gene with l oss of the normal allele in a low-grade mixed glioma which has not rec urred during 4-year follow-up. The tumor had a low 5-bromodeoxyuridine (BrdU)-labeling index and low AgNOR count. The p53 protein was not de tected on immunochemical staining. To our knowledge, this is the first report of an altered p53 gene in a low-grade nonrecurrent glial tumor and highlights the presence of further checks and balances on the con trol of cell proliferation and other malignancy-associated phenotypes, even in an already-established tumor.