TRISOMY-11 AND OTHER NONRANDOM TRISOMIES IN CONGENITAL FIBROSARCOMA

Authors
BERNSTEIN R ZELTZER PM LIN F CARPENTER PM
Citation
R. Bernstein et al., TRISOMY-11 AND OTHER NONRANDOM TRISOMIES IN CONGENITAL FIBROSARCOMA, Cancer genetics and cytogenetics, 78(1), 1994, pp. 82-86
Citations number
22
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
78
Issue
1
Year of publication
1994
Pages
82 - 86
Database
ISI
SICI code
0165-4608(1994)78:1<82:TAONTI>2.0.ZU;2-P
Abstract
Chromosome studies in a 7-week-old female infant with an intraabdomina l malignant fibrosarcoma showed a hyperdiploid karyotype of 50,XX, +de r(6)del(6)(p23)add(6)(q11), +8, +10, +11,add(12)(p13). Trisomy 11 appe ars to be a nonrandom primary cytogenetic abnormality in the congenita l or infantile form of this mesenchymal tumor and is also a nonrandom gain in congenital mesoblastic nephroma. A possible developmental link between these two mesenchymal tumors, mediated by a gene or genes on chromosome 11 is postulated.