G. Belge et al., CYTOGENETIC BICLONALITY CORRESPONDING TO MULTIPHASIC DIFFERENTIATION IN AN ATYPICAL THYROID ADENOMA, Cancer genetics and cytogenetics, 78(1), 1994, pp. 102-104
Cytogenetic aberrations have been described in about 30% of benign thy
roid tumors, but their role for tumorigenesis or progression has not y
et been elucidated. We describe the cytogenetic analyses in a thyroid
adenoma with two different clonal cytogenetic stemlines: 45,XX,der(1)t
(1;14)(p13;q11.2 -(q3.3),t(5;12)(q11.2;q24),del(9)(q12), 9)(p15;q13),d
er(14)t(14;15)(q13;q23),del(15)(q23), q13)/46,X,?inv(x),?inv(3)(p21q29
),t(3;8)(q26;q12). Histologic examination revealed an atypical follicu
lar thyroid adenoma containing microfollicular, follicular, trabecular
-solid, and oncocytic components. There may be a direct relation betwe
en the different cytogenetic stemlines and the histologic diversity of
the tumor. Thyroid tumors with complex karyotypes involving the 19q13
breakpoint may represent advanced stages of karyotypic evolution and
therefore warrant an extensive clinical follow-up.