LOW ACTIVITY OF CIRCADIAN CONTINUOUS FLUORODEOXYURIDINE (FUDR) CHEMOTHERAPY IN POOR-PROGNOSIS METASTATIC RENAL-CANCER

Authors
MIGLIETTA L CANOBBIO L CANNATA D CUROTTO A BERTIRIBOLI F GIULIANI L BOCCARDO F
Citation
L. Miglietta et al., LOW ACTIVITY OF CIRCADIAN CONTINUOUS FLUORODEOXYURIDINE (FUDR) CHEMOTHERAPY IN POOR-PROGNOSIS METASTATIC RENAL-CANCER, Oncology Reports, 1(1), 1994, pp. 121-123
Citations number
28
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
1
Issue
1
Year of publication
1994
Pages
121 - 123
Database
ISI
SICI code
1021-335X(1994)1:1<121:LAOCCF>2.0.ZU;2-G
Abstract
Thirteen patients with progressive metastatic renal cell carcinoma wer e treated with circadian continuous Fluorodeoxyuridine (FUDR) infusion s. The drug was delivered according to the variable rate infusion of H rushesky protocol. All patients had previously received and failed sys temic treatment and presented more than one metastatic site. The toxic ity was low, however, no objective responses were observed. Despite pr evious reports of activity of FUDR in metastatic renal cancer, we sugg est that the present regimen cannot be recommended in poor prognosis m etastatic renal cancer.