We present a case of orbital lipogranuloma with a supero-nasal retrobu
lbar localisation associated with axial proptosis and major choroidal
thickening. No clinical sign of inflammation, neither orbital nor in t
he posterior segment, was revealed. The systemic work-up as well as pa
raclinical data were within normal limits. The diagnosis was made afte
r histopathologic examination of the biopsy taken via superior orbit.
Outcome was favorable following long-term systemic corticotherapy. Orb
ital lipogranuloma is a rare particular form of orbital pseudotumour o
f unknown etiology. It is characterized, histologically, by orbital fa
t necrosis. Pathogenesis remains controversial. The differential diagn
osis includes iatrogenic lipogranulomas secondary to sinus surgery (pa
raffinoma), orbital granulomas in sarcoidosis and Wegener's disease an
d orbital lymphomas. The prognosis is usually good following treatment
with steroids.