SUCCESSFUL TREATMENT RESPONSE OF GRANULOMA-ANNULARE AND CARPAL-TUNNELSYNDROME TO CHLORAMBUCIL

We describe a 62-year-old woman in whom skin biopsies verified the cli nical diagnosis of granuloma annulare and neurologic and electromyogra phic studies confirmed the neurologic diagnosis of carpal tunnel syndr ome. Short-term treatment with a low dose of chlorambucil taken orally was prescribed. Within weeks, the granuloma annulare had disappeared, and the clinical symptoms of carpal tunnel syndrome had resolved. Ele ctromyography showed variable improvement at the end of treatment and resolution at 9-month follow-up. Our case confirms that short-term tre atment of granuloma annulare and associated carpal tunnel syndrome wit h low-dose chlorambucil is successful.